raloxifene hydrochloride
CLINICAL USE
Treatment and prevention of osteoporosis in post-menopausal women
DOSE IN NORMAL RENAL FUNCTION
60 mg daily
PHARMACOKINETICS
Molecular weight                           :510 %Protein binding                           :98–99 %Excreted unchanged in urine     : <0.2 Volume of distribution (L/kg)       :2348half-life – normal/ESRD (hrs)      :27.7/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in normal renal function HD                     :Unlikely to be dialysed. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants: antagonism of anticoagulant effect of coumarinsColestyramine: reduced absorption of raloxifene – avoid concomitant use ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
There are case reports of it being beneficial in females on haemodialysis and also a benefit to the lipid profile. (Hernandez E, Valera R, Alonzo E, et al. Effects of raloxifene on bone metabolism and serum lipids in post-menopausal women on chronic haemodialysis. Kidney Int. 2003; 63(6): 2269–74.)This study showed that raloxifene could reduce vertebral fractures although they were more likely to suffer from side effects. (Ishani A, Blackwell T, Jamal SA, et al. The effect of raloxifene treatment in post-menopausal women with CKD. J Am Soc Nephrol. 2008; 19:1430–8.)Manufacturer advises use is contraindicated in severe renal impairment due to lack of data rather than known toxicity< 6% of dose is excreted in the urine
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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